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Mitragynine is the major active alkaloid in the plant. Kratom Effects High Dose to date the role of mitragynine in psychological disorders such as depression is not scientifically evaluated. Ekkasit Kumarnsita Niwat Keawpradubb and Watcharin Nuankaewc aDepartment of Physiology Faculty of Science Department of Pharmacognosy and Pharmaceutical Botany Faculty of Pharmaceutical Sciences PSU Hat-Yai Thailand. Moreover the long-term administration also significantly suppressed weight gaining.

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