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Metabolism studies of the Kratom alkaloids mitraciliatine and isopaynantheine diastereomers of the main alkaloids mitragynine and paynantheine in rat and human urine using liquid chromatography-linear ion trap-mass spectrometry. Metabolism studies of the Kratom alkaloid speciociliatine a diastereomer

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The Transnational Institute has argued that while continued research is needed the criminalization of kratom is unfounded and is based on economic control and disinformation. This group has argued that few records are available showing negative health or social consequences from kratom consumption but despite this fact kratom is becoming increasingly subject to actions of law enforcement in numerous countries. The criminalization of kratom has created numerous barriers for research.

At the time the government was levying taxes from users and shops involved in the opium trade. Because of the increasing opium costs many users were switching to kratom to manage their withdrawal symptoms. However the launch of the kratom 15x bluelight Greater

East Asia War in 1942 and declining revenues from the opium trade pushed the Thai indo kratom leaf government into action to curb and suppress competition in the opium market by making kratom illegal.