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There is always some confusion related to use of these terms. Mutagenesis is important in the carcinogenesis process however not all carcinogenesis is due to mutagens. This is due to the fact that carcinogenesis could also occur via epigenetic (not involving the DNA) mechanisms.
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The cannabis plant is widely abused as a recreational drug and is well known as marijuana ganja and has many other street names (Watts 2006). Other alternatives drugs of the kappaopioid group such as nalbuphine pentazocine and butharphanol were clinically available as morphine alternatives but he controversy around the actual analgesic effects of these drugs remain debated (ScienceDaily 2000). Other specific plants which are frequently used by the public and have direct and indirect effects on the central nervous system include Ephedra or Ma huang (Ephedra spp) which are good nasal decongestants due to vasodilation effects however can also stimulate CNS side effects from nervousness to imsomnia; gingko (Gingko biloba L.
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When the DNA damage occurs during cell cycle phases such as during DNA replication correction needs to be performed to avoid permanent mutation in subsequent DNA replications. A repair system called mismatch repair (MMR) recognises and repairs the erroneous insertion deletion and mis-incorporation during DNA replications and also recombination (Iyer et al 2006). C pairing bases will be repaired by Buy Kratom In Us excising the wrong bases and replace it with the right nucleotides. Exogenous DNA damaging agents or endogenous ROS formation can cause double DNA strand Buy Kratom In Us breaks (DSBs) which promote genome rearrangements and thus initiate maeng da kratom powder dosage carcinogenesis or apoptosis ( Hoiejmakers 2001; Alteiri et al 2008). Therefore the evolved mammalian system has two mechanisms to repair such damage. The first is by homologous recombination (HR) and use instructions from sister or homologous chromosomes for a proper repair of the breaks.
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More than 130 human genes have been found to be involved in DNA repair mechanisms (Wood et al 2001). As soon as the damage has been indentified specific molecules are brought to the site of damage and induce other molecules to bind and form a complex for repair. Most of the time if small areas of DNA are affected such as in nearly all oxidative damage (e.