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The safety assessment assumptions suggest that the use of kratom extract vs resin Mitragyna speciosa Korth leaves within the range of pharmacologically active doses as

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reported in the literature is probably safe however caution should be taken Buy Cheap Kratom Powder as MSE toxicity in this study was found to be enhanced by metabolism particularly by CYP 2E1. Thus the combination consumption of Mitragyna speciosa Korth leaves with CYP 2E1 inducers may shift toxicity closer to doses that are pharmacologically active. Buy Cheap Kratom Powder based on the current findings observed in the present studies it is concluded that the methanol-chloroform extract (MSE) of the Mitragyna speciosa Korth (Kratom) leaves and its dominant alkaloid mitragynine (MIT) have potential to cause cytotoxicity to mammalian cells at high doses and is possibly harmful to human users. MIT is proposed to be a major contributor to MSE cytotoxicity.

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As shown in the table 3. MLA results for MIT in the presence or absence of rat liver S9 show no evidence of genotoxicity. The outcome of this experiment would seem to be contrary to what was seen for MSE.

Whereas for MIT as shown in previous 4 hr incubation time point similar results were observed for both MIT treated groups. These results suggest that caspase 3 and 7 activities were more pronounced in MIT treated cells and are likely not to be involved in the MSE treated cells. SH-SY5Y cells treated with various concentrations of MSE and MIT at A) 4 hr and B) 18 hr incubation time period. MSE treated SH-SY5Y cells was not established in my preliminary experiments further assays were carried out to confirm this finding. The inhibitors used were caspase 3 inhibitor caspase 8 inhibitor caspase 9 inhibitor general caspase inhibitor negative control and doxorubicin as a positive control ( as described in section 5. The positive control doxorubicin confirmed the assay works by showing a highly significant response for apoptosis.

SH-SY5Y cells treated with chloroform in ethanol vehicle (Fig. If chloroform contamination of MSE contributed to the toxicity of MSE then addition or synergistic cytotoxicity would be expected. M CHCl3) (Fig.