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However the RTG was in the toxic range (10-20% reduced of the concurrent vehicle control). In
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addition the cloning efficiency of the cells or RSG value prior plating was also quite low (24%). On this basis it was assumed that the positive effect was due to the excessive cytotoxicity in line with the ICH S2A guidelines (1995) and the result is considered keep kratom legal petition invalid. The other concentrations tested were negative for genotoxic potential. The presence of S9 appeared to have a substantial effect on the RTG with MSE. In fact there was a clear dose-dependant toxicity observed suggesting that the MSE was being activated to a toxic derivatives. MSE in the absence of metabolic activation with S9 did not produce evidence of genotoxicity (Table 3.
Apart from the effects of using this plant seen with traditional users and drug addicts as described previously in chapter 1(section 1. With the introduction of legislation against possession of this plant in Malaysia the access of this plant to the public especially to drug addicts is now under tighter control. Like many other traditional remedies Bali Kratom Tincture that exist in the market the potential toxicity of this plant and its derivatives
are not fully known.
Effects of MSE and MIT on p53 target gene product p21 It is well established that induction of p53 can lead to expression of target gene p21 and thereby cell cycle arrest. MSE even kratom buprenorphine withdrawal at the buy kratom extract online kratom for mild opiate withdrawal earliest time point 6 hr. Therefore to further determine whether p21 is positively linked with p53 in response to MSE or MIT we examined p21 levels using immunoblots. The quantitation of p21 protein is described in section 4. There was a clear up regulation of p21 protein seen for the control group at kratom side effects nausea 24 and 48 hours consistent with the upregulation of p53 noted earlier.